Tim Formosa highlighted in GENETICS

Dr. Tim Formosa's publication: "Establishment and Maintenance of Chromatin Architecture Are Promoted Independently of Transcription by the Histone Chaperone FACT and H3-K56 Acetylation in Saccharomyces cerevisiae", has been chosen to be highlighted in the March 2019 edition of GENETICS! Click here to see the abstract.

"Using a combination of in vitro biochemistry, genetics, and genomics, McCullough and Pham et al. explore how the histone:DNA contact at the entry/exit site of nucleosomes affects the functions of the histone chaperone FACT in the yeast Saccharomyces cerevisiae. They find that FACT and histone H3-K56 acetylation collaborate to establish the appropriate chromatin architecture. This role appears to be important for maintaining the features of chromatin independent of ongoing transcription as well as in response to the effects of transcription on chromatin integrity"